Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (1074)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Inhibitors (643)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-110184

PK-THPP	Inhibitor	99.4%
PK-THPP is a potent and brain-penetrant TWIK-related acid-sensitive K⁺ ion channel (K2P9.1 or TASK-3) blocker with IC₅₀s of 35 nM and 300 nM for TASK-3 and TASK-1, respectively. PK-THPP shows no or less activity against other K⁺ channels. PK-THPP is an effective breathing stimulant and can be used for the study of breathing disorders.

HY-44153

KV2 channel inhibitor-1	Inhibitor	98.73%
KV2 channel inhibitor-1 is a selective K_V2 channel inhibitor with IC₅₀s of 0.2 μM and 0.41 μM for K_V2.1 and K_V2.2, respectively. KV2 channel inhibitor-1 possesses good selectivity over K_V1.2 (IC₅₀>10 μM). KV2 channel inhibitor-1 is >10-fold selective over Na_V channels and other K_V channels and displays weak activity on Ca_V channels.

HY-107319

Almitrine mesylate	Inhibitor	98.88%
Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca²⁺-dependent K⁺ channel.

HY-134320B

8-Azido-ATP trisodium solution (100 mM)	Inhibitor	98.13%
8-Azido-ATP (8-N3-ATP) trisodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP trisodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP trisodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-124108

Eicosatetraynoic acid	Inhibitor	99.9%
Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid (HY-109590) and also an inhibitor of the lipoxygenase (LOX)/cyclooxygenase (COX) pathway (ID₅₀= 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene.

HY-18600

Azimilide	Inhibitor	99.01%
Azimilide (NE-10064) is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide is a dual blocker of I_Ks (IC₅₀ = 2.6 μM (2mM [K⁺]ₑ)) and I_Kr (IC₅₀ = 1 μM (4 mM [K⁺])). Azimilide blocked HERG channel at 0.1 and 1 Hz with IC₅₀s of 1.4 μM and 5.2 μM respectively. Azimilide also inhibits L-type calcium current (I_Ca) (IC₅₀ = 17.8 μM) and sodium current (I_Na) (IC₅₀ = 19 μM). Azimilide can be used for the study of atrial fibrillation and ventricular fibrillation.

HY-162549

CPK20	Inhibitor	99.67%
CPK20 is a potent and highly selective KCNT1 channel blocker, and CPK20 can be used in the study of epilepsy.

HY-163996

DD202-114	Inhibitor	99.27%
DD202-114 is a potent and selective GLP1R agonist. DD202-114 inhibits hERG with an IC₅₀ of 15.9 μM. DD202-114 exhibits strong CYP2C8 inhibition with an IC₅₀ of 0.22 μM. DD202-114 promotes cAMP accumulation. DD202-114 reduces blood glucose levels and food intake. DD202-114 has the potential to be used in the study of type 2 diabetes mellitus (T2DM) and obesity.

HY-148304A

VU6036720 hydrochloride	Inhibitor	99.65%
VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 hydrochloride can inhibit Kir4.1/5.1 channels with an IC₅₀ value of 0.24 μM. VU6036720 hydrochloride can be used for the research of brain and kidney.

HY-108574

CP 339818 hydrochloride	Inhibitor	99.61%
CP 339818 hydrochloride is a non-peptide Kv1.3 channel (IC₅₀ = 200 nM) and Kv1.4 channel blocker. CP 339818 hydrochloride inhibits HCN channel with IC₅₀s of 18.9 μM and 43.4 μM against HCN1 and HCN4 (high Cl^-). CP 339818 hydrochloride has significantly weaker blocking effects on Kv1.1, Kv1.2, Kv1.5, Kv1.6, Kv3.1-4, and Kv4.2 channels. CP 339818 hydrochloride selectively blocked Kv1.3, thereby inhibiting the activation process of human T cells. CP 339818 hydrochloride can be used to study the physiological functions of HCN and Kv channels.

HY-108592

UCL 2077	Inhibitor	98.91%
UCL 2077 is a potassium channel and slow afterhyperpolarization (sAHP) inhibitor. UCL 2077 selectively blocks sAHP channels without affecting L-type Ca²⁺ currents. UCL 2077 blocks KCNQ1- and KCNQ2-containing K⁺ channels, decreases erg current amplitude, increases erg deactivation rate. UCL 2077 can be used for the research of hippocampus-dependent memory retrieval deficit and cardiac arrhythmias.

HY-161104

Kv2.1-IN-1	Inhibitor	98.64%
Kv2.1-IN-1 is an orally active and blood-brain barrier penetrant Kv2.1 inhibitor with an IC₅₀ of 0.07 μM. Kv2.1-IN-1 exhibits a selectivity >130 fold over other K⁺, Na⁺, and Ca²⁺ ion channels. Kv2.1-IN-1 decreases the apoptosis of HEK293 cells induced by H₂O₂. Kv2.1-IN-1 produces significant neuroprotection efficacy in middle cerebral artery occlusion (MCAO) rat. Kv2.1-IN-1 can be used for the study of ischemic stroke.

HY-15707

NS6180	Inhibitor	99.76%
NS6180 is a new orally active KCa3.1 channel inhibitor. NS6180 inhibits cloned human KCa3.1 channels with an IC₅₀value of 9 nM. NS6180 can be used for the research of inflammatory bowel disease (IBD) .

HY-121685A

Tipepidine hydrochloride	Inhibitor	99.98%
Tipepidine hydrochloride reversibly inhibits dopamine (DA) D₂ receptor-mediated GIRK currents (I_DA(GIRK)) with an IC₅₀ of 7.0 μM. Tipepidine hydrochloride subsequently activates VTA dopamine neuron. Tipepidine hydrochloride, a non-narcotic antitussive, exerts an antidepressant-like effect.

HY-N6790

Nonactin	Inhibitor	99.0%
Nonactin is a macrotetrolide antibiotic and mitochondrial uncoupler with antibacterial, insecticidal, and acaricidal activities. Nonactin acts as an ionophore for monovalent cations, including K⁺, and NH₄⁺, and it can also inhibit the surface expression of endogenous HSP60. In addition, Nonactin can induce apoptosis in β-catenin mutant tumor cells and has anti-tumor activity.

HY-B1482A

Mesoridazine	Inhibitor	99.48%
Mesoridazine (TPS-23) , a metabolite of Thioridazine (HY-B0965A), acts as an orally active phenothiazine antipsychotic agent. Mesoridazine is a potent and rapid open-channel blocker of human ether-a-go-go related gene (hERG) channels and blocks hERG currents with an IC₅₀ of 550 nM (at 0 mV) in human embryonic kidney 293 cells.Mesoridazine can be used for the research of schizophrenia, as well as certain other psychiatric disorders.

HY-108583

Psora-4	Inhibitor	99.7%
Psora-4 is a potent and selective inhibitor of K_v1.3 (voltage-gated potassium channels) with an EC₅₀ of 3 nM. Psora-4 has immunosuppressive activity and inhibits proliferation of human and rat myelin-specific effector memory T cells in vitro.

HY-B0480

Brompheniramine maleate	Inhibitor	99.93%
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a K_d of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC₅₀s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research.

HY-P3581

PE 22-28	Inhibitor	99.98%
PE 22-28 is a TREK-1 inhibitor with IC₅₀ value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression.

HY-B1193R

Terfenadine (Standard)	Inhibitor
Terfenadine (Standard) is the analytical standard of Terfenadine. This product is intended for research and analytical applications. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

321compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (1074)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (1074):